منابع مشابه
Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain.
Prostaglandin E2 (PGE2) is the major primary prostaglandin generated by brain cells. However, the coordination and intracellular localization of the cyclooxygenases (COXs) and prostaglandin E synthases (PGESs) that convert arachidonic acid to PGE2 in brain tissue are not known. We aimed to determine whether microsomal and cytosolic PGES (mPGES-1 and cPGES) colocalize and coordinate activity wit...
متن کاملInvolvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia.
After engulfment of apoptotic cells through phosphatidylserine (PS)-mediated recognition, microglia secrete prostaglandin E2 (PGE2), a potent anti-inflammatory molecule in the central nervous system. Despite the clinical significance, the mechanism underlying PGE2 production by phagocytosis of apoptotic cells is poorly understood. In the present study, we used PS liposomes to elucidate the phag...
متن کاملIntracellular-specific colocalization of prostaglandin-E2 synthases and cyclooxygenases in brain
Prostaglandin E2 (PGE2) is the major primary prostaglandin generated by brain cells. However, the coordination and intracellular localization of the cyclooxygenases (COX) and prostaglandin E synthases (PGES) which convert arachidonic acid to PGE2 in brain tissue is not known. We aimed to determine if microsomal and cytosolic PGES (m-PGES-1 and cPGES) colocalize and coordinate activity with eith...
متن کاملProstaglandin E synthases in zebrafish.
OBJECTIVE Prostaglandin E synthases (PGESs) are being explored as antiinflammatory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE(2) formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation. We sought to characterize the developmental expression of COX and PGES in zebrafish. METHODS AND RESULTS We cloned zeb...
متن کاملIntrarenal Prostaglandin Synthases and Phospholipase A
In chronic hypercalcemia, inhibition of thick ascending limb sodium chloride reabsorption is mediated by elevated intrarenal PGE 2 . The mechanisms and source of elevated PGE 2 in hypercalcemia are not known. We determined the effect of hypercalcemia on intrarenal expression of cytosolic phospholipase A 2 (cPLA 2 ), prostaglandin H synthase-1 (PGHS-1), and prostaglandin H synthase-2 (PGHS-2), e...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2002
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.120.373